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FACULTY - PRIMARY FACULTY - KRISTIAN E. BAKER |
Kristian E. Baker, Ph.D.
Instructor
Center for RNA Molecular Biology
|
RNA Center Faculty: since 09-2005 |
Education: Ph.D.: Genetics & Molecular Biology Postdoc: Howard Hughes Medical Institute, University of Arizona, 2002-2005 |
Research:
Mechanism of nonsense-mediated mRNA
decay in Saccharomyces cerevisiae.
mRNA harboring a premature termination codon is subject to rapid degradation by the nonsense-mediated mRNA decay (NMD) pathway. While the precise mechanism involved in discriminating NMD substrates from mRNA that is not targeted to NMD is unclear, the spatial relationship between the premature termination codon and additional features of the mRNA plays a critical role. My research focuses on determining how the various mRNA features contribute to NMD substrate recognition and how substrate recognition is translated into changes to the mRNA that result in repression of translation and susceptibility of the RNA to multiple pathways of degradation.
Selected Publications
Baker, K.E. and Parker, R. (2006)
Features of Nonsense- mediated mRNA Decay in Saccharomyces cerevisiae.
In “Nonsense-mediated mRNA decay”, ed. Lynne E. Maquat, Landes Biosciences, Austin, Texas, in press.
Baker, K.E., Coller, J., and Parker, R. (2004)
The yeast Apq12 protein affects nucleocytoplasmic mRNA transport.
RNA 10:1352-1358. 
Baker, K.E. and Parker R. (2004)
Nonsense-mediated mRNA decay: terminating erroneous gene expression.
Curr Opin Cell Biol. 16:293-299.
Baker, K.E. and Mackie, G.A. (2003)
Ectopic RNase E sites promote bypass of 5'-end-dependent mRNA decay in Escherichia coli.
Mol Microbiol. 47:75-88.
Baker, K.E., DiTullio, K.P., Neuhard, J., and Kelln, R.A. (1996)
Utilization of orotate as a pyrimidine source by Salmonella typhimurium and Escherichia
coli requires the dicarboxylate transport protein encoded by dctA.
J. Bact. 178:7099-7105.